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Target intelligence / Profile preview
BMERB domain-containing protein 1 (BMERB1)
- Target
- BMERB1
- Molecular classification
- Other (Rab effector protein family), bMERB domain-containing protein (belongs to the Mical/EHBP protein families, not classically recognized as enzyme, receptor, transporter, channel, or transcription factor)
01
Overview
BMERB domain-containing protein 1 (BMERB1) encodes a protein characterized by the bMERB domain. This domain is a bivalent Mical/EHBP Rab binding motif, functioning as a Rab8 family effector evolved by gene duplication. The BMERB domain enables the protein to bind with high specificity to Rab8 family small GTPases, including Rab8, Rab10, Rab13, and Rab15, which are key regulators of endosomal trafficking. BMERB1 is predicted to be involved in the negative regulation of microtubule depolymerization and cell motility, especially in radial glia-guided migration in the cerebral cortex. It is expressed in several tissues, including the central nervous system. The protein is not recognized as a therapeutic target, nor are there known drugs or established biomarker roles for it. Disease associations according to genetic databases include Noonan Syndrome 10 and Lynch Syndrome 1. The molecular architecture and evolutionary history of the bMERB domain indicate specialized cellular trafficking and cytoskeletal roles, but its detailed physiological and pathological implications remain under investigation.
- Other names
- BMERB1C16orf45FLJ32618MINPMigration inhibitory proteinUncharacterized protein C16orf45bMERB domain-containing protein 1
02
Mechanism of action
No drugs known to directly interact; mechanism not established
03
Biological functions
Involved in negative regulation of microtubule depolymerizationNegative regulation of cell motility, particularly in cerebral cortex radial glia-guided migrationMay act in endosomal trafficking by binding Rab8 family small GTPasesPredicted to be active in the microtubule cytoskeleton
04
Disease associations
Noonan Syndrome 10Lynch Syndrome 1
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