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Target intelligence / Profile preview
BMI1 proto-oncogene, polycomb ring finger pseudogene 1 (BMI1P1)
- Target
- BMI1P1
- Molecular classification
- Pseudogene, Long non-coding RNA
01
Overview
BMI1 proto-oncogene, polycomb ring finger pseudogene 1 (BMI1P1) is a **pseudogene** of the BMI1 proto-oncogene. BMI1P1 does not code for a functional protein, but may be transcribed as a long non-coding RNA (lncRNA), sometimes called lnc-OPHN1-5. As a pseudogene, BMI1P1 itself is not considered a classic drug target such as a receptor, enzyme, or transporter. Its only role may be indirect regulation of gene expression by serving as a decoy or sponge in competitive endogenous RNA (ceRNA) networks, possibly affecting the expression of its functional parent gene, BMI1, which has well-established oncogenic functions. However, there is no evidence that BMI1P1 is a validated therapeutic target or biomarker, and its molecular and functional biology is poorly characterized compared to BMI1[5].
- Other names
- lnc-OPHN1-5BMI1 polycomb ring finger oncogene pseudogeneBMI1P1
02
Biological functions
Regulatory RNAGene expression modulation (may compete with microRNAs and participate in ceRNA networks)Does not encode a functional protein
03
Disease associations
No direct, established roles as a protein or classic lncRNA disease targetRelated BMI1 gene is implicated in cancer, but not this pseudogene
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