BMP-binding endothelial regulator protein (BMPER)

BMP-binding endothelial regulator protein (BMPER) is a secreted extracellular matrix glycoprotein expressed by endothelial cell precursors and mature endothelial cells. It contains five cysteine-rich domains, a von Willebrand D domain, and a trypsin inhibitor domain, and is orthologous to Drosophila crossveinless-2. BMPER directly binds BMP2, BMP4, and BMP6, and finely tunes their signaling in a highly context-dependent manner, acting as either an antagonist or agonist of BMP-mediated Smad1/5 activation. It plays a vital role in blood vessel formation, endothelial cell migration, embryonic vascular development, and also interacts with metabolic and insulin signaling pathways. BMPER modulates angiogenesis by dose-dependent regulation of BMP activity and is considered a potential therapeutic target for vascular diseases and metabolic disorders[1][2][3][4][5].

Other names

BMPERKIAA1965hCV2Cv2CRIM3Bone morphogenetic protein-binding endothelial cell precursor-derived regulatorProtein crossveinless-2crossveinless-2CV-2CV2BMP-binding endothelial regulator precursor protein

Not applicable, as no direct drugs targeting BMPER are reported or approved. Existing research focuses on BMPER modulation of BMP ligands and their receptors.