BolA family member 2B (BOLA2B)

BolA family member 2B (BOLA2B) is a protein-coding gene recently characterized through advanced human genome projects. It encodes a BolA family protein involved in maintaining normal cell shape, regulating cell division, and assembling iron–sulfur clusters crucial for cellular redox reactions and electron transport[1][3]. BOLA2B is expressed in both nuclear and cytoplasmic compartments and interacts with glutaredoxin proteins (GLRX3, GLRX5), contributing to iron metabolism and homeostasis. Pathologically, BOLA2B is highly expressed in various tumors (notably hepatocellular carcinoma and ovarian cancer), where it drives cancer progression through activation of mTORC1 and c-MYC signaling, and is associated with poorer prognoses. It may function as a transcription factor and participates in pathways regulating cell cycle (especially G2/M checkpoint), autophagy, and PI3K-AKT signaling[1][3]. Due to its role in tumor biology and iron metabolism, BOLA2B represents a novel candidate as a therapeutic target and biomarker for cancer, although no drugs currently target it directly. Note: Information about BOLA2B is rapidly evolving due to its recent discovery; details on clinical relevance or therapeutic targeting may change as research progresses[1][3].

Other names

BolA-like protein 2BOLA2BOLA2AMy016BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B