Bombesin receptor-activated protein (BRAP)

Bombesin receptor-activated protein (BRAP) is a multifunctional protein encoded by the C6orf89 gene, serving as an enhancer of histone deacetylase activity to regulate chromatin remodeling, immune response, and cell proliferation. The protein exists as several isoforms that localize to the nucleolus, Golgi, and midbody, integrating into cellular structures associated with ribosome biogenesis, mitosis, and wound repair. BRAP modulates immune and inflammatory responses, particularly in airway epithelial cells, through HDAC-mediated suppression of NF-κB, influencing cell repair and immune surveillance. Dysregulation of BRAP is implicated in diseases including cancer, kidney injury, and congenital glycosylation disorders, where it shapes cell fate and drug response through epigenetic and transcriptional mechanisms

Other names

Bombesin receptor-activated proteinBRAPChromosome 6 open reading frame 89C6orf89AmfionPS1TP5TP1FLJ25357UNQ177/PRO203

Enhancement of histone deacetylase (HDAC) activity; Suppression of NF-κB transcriptional activity; Regulation of ribosomal gene transcription; Modulation via effects on SIRT2 in kidney injury