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Target intelligence / Profile preview
Bone Hydroxyapatite Crystal (HAP)
- Target
- HAP
- Molecular classification
- Mineral, Inorganic crystal
01
Overview
Bone hydroxyapatite (HAP) is the primary mineral component of bone, responsible for its rigidity and mechanical strength. It is a naturally occurring form of calcium phosphate with the chemical formula Ca₁₀(PO₄)₆(OH)₂. HAP provides bones with compressive strength and supports osseointegration. It is a target for drugs like bisphosphonates and can be utilized for targeted drug delivery to bone tissue.
- Other names
- HydroxyapatiteCalcium phosphateBone mineral
02
Mechanism of action
Bisphosphonates bind to hydroxyapatite and inhibit osteoclast activity. Phytate binds to growth sites on hydroxyapatite crystals, inhibiting calcification.
03
Biological functions
Bone mineralizationCalcium reservoirOsseointegrationBone compressive strength
04
Disease associations
OsteoporosisBone metastasisCardiovascular calcificationDental cariesKidney stones
05
Safety considerations
Ectopic calcificationOver-suppression of bone turnover (with bisphosphonates)Potential for off-target effects in drug delivery
06
Interacting drugs
Bisphosphonates
1 more in the full profile.
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