Bone marrow hematopoietic progenitor cells (HSPC)

Bone marrow hematopoietic progenitor cells are a diverse group of immature blood-forming cells residing in the bone marrow, responsible for the continuous regeneration of all blood cell types, including lymphoid and myeloid lineages. They include both long-term self-renewing hematopoietic stem cells (HSCs) and lineage-committed multipotent or oligopotent progenitors. These cells are essential for normal hematopoiesis, can be therapeutically harnessed in bone marrow transplantation, and are implicated in malignancies such as leukemia when their differentiation or self-renewal capacity is dysregulated. Their identification relies on specific cell surface antigens (e.g., CD34, c-Kit), and they are studied as targets for both regenerative medicine and chemotherapeutic strategies, but the population itself is not a receptor or discrete molecular entity.

Other names

Hematopoietic progenitor cellHematopoietic stem cell (HSC)Bone marrow stem cellHSPC