Bone marrow kinase on chromosome X (BMX)

Bone marrow kinase on chromosome X (BMX) is a cytosolic, non-receptor tyrosine kinase belonging to the Tec family, predominantly expressed in hematopoietic cells of the myeloid lineage, endothelial and epithelial cells, and various tumor types. BMX modulates signal transduction pathways that impact cell migration, survival, proliferation, and immune responses, notably via regulation of cytokine secretion and angiogenesis. Its kinase domain is well characterized structurally, with several inhibitors reported to bind its ATP pocket, and research supports its therapeutic potential for targeting cancer, cardiovascular disease, and inflammatory disorders. No pathogenic mutations have been conclusively associated with human disease so far, distinguishing it from its close relative BTK, which causes X-linked agammaglobulinemia when mutated.

Other names

BMX protein, humanCytoplasmic tyrosine-protein kinase BMXBone marrow tyrosine kinase gene in chromosome X proteinEpithelial and endothelial tyrosine kinase (ETK)NTK38Tyro8PSCTK3

ATP-competitive inhibition of BMX kinase activity; Blockade of signal transduction pathways involved in cellular proliferation, survival, and migration; Inhibition of angiogenesis and cytokine-mediated inflammatory responses