Bone marrow mesenchymal stem cell (BM-MSC)

Bone marrow mesenchymal stem cell (BM-MSC) refers to a population of non-hematopoietic, multipotent, plastic-adherent adult stem cells principally resident in the bone marrow but also identifiable in other tissues[1][2][4]. BM-MSCs are characterized by their ability to self-renew and to differentiate into multiple mesenchymal lineages, such as bone (osteoblasts), fat (adipocytes), cartilage (chondrocytes), and, under certain conditions, muscle and other cell types[1][3][5]. In addition to their differentiation potential, BM-MSCs secrete a variety of bioactive molecules, thereby modulating tissue repair, immune responses, and inflammation primarily through paracrine mechanisms rather than by direct replacement of damaged cells[3][4][6]. They form a significant component of the hematopoietic niche in the marrow, supporting hematopoietic stem cells, and are under clinical investigation for use in regenerative medicine and immunomodulatory therapies[2][6]. There are challenges in their use, including heterogeneity of populations, risk of senescence, and the theoretical risk of malignant transformation upon extensive culture[2]. Note: BM-MSCs, as a cell population, are not a therapeutic target in the sense of a molecular drug target (receptor, enzyme, transporter). Rather, they are a source of cellular therapeutics, acting as living drugs in cell therapy. Thus, "Bone marrow mesenchymal stem cell" is not a canonical molecule or receptor target; it is a heterogeneous cell population[2][3][5]. Because of this, the entry is marked as is_incorrect: true for a molecule/receptor target list.

Other names

Mesenchymal stromal cell (bone marrow)MSC (bone marrow)Bone marrow MSCBM stromal cell