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Target intelligence / Profile preview
Bone marrow stromal cell antigen 1 (CD157)
- Target
- CD157
- Molecular classification
- Ectoenzyme, GPI-anchored membrane protein, ADP-ribosyl cyclase family
01
Overview
Bone marrow stromal cell antigen 1 (CD157), also known as BST1, is a multifunctional cell surface molecule with both enzymatic and receptor activities. It catalyzes the conversion of NAD+ to cyclic ADP-ribose (cADPR) and acts as a receptor for extracellular matrix proteins like fibronectin. It plays roles in leukocyte migration, immune surveillance, and macrophage-mediated killing of Mycobacterium tuberculosis. CD157 is overexpressed in several diseases, including rheumatoid arthritis and acute myeloid leukemia (AML), and is being explored as a therapeutic target.
- Other names
- BST1ADP-ribosyl cyclase 2
02
Mechanism of action
Targeted therapy against AML cells using monoclonal antibodies
03
Biological functions
Calcium signaling regulationLeukocyte migrationAdhesionTransmigrationImmune surveillanceHumoral immunityMacrophage-mediated killing of Mycobacterium tuberculosisRegulation of self-renewal and migration of mesenchymal stem cells
04
Disease associations
Rheumatoid arthritisAcute myeloid leukemia (AML)Ovarian cancerParkinson’s diseaseAcute kidney injury
05
Interacting drugs
MEN1112/OBT357
06
Biomarkers
Expression levels in AML blasts for diagnosisGenetic polymorphisms for disease susceptibility/progression risk
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