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Target intelligence / Profile preview
Bone Marrow Stromal Cell Antigen 2 (BST2)
- Target
- BST2
- Molecular classification
- Transmembrane protein, Glycoprotein
01
Overview
Bone Marrow Stromal Cell Antigen 2 (BST2), also known as CD317 or Tetherin, is a transmembrane protein expressed on various cell types, most notably bone marrow stromal cells and plasmacytoid dendritic cells (pDCs). It plays a role in innate immunity by restricting the release of enveloped viruses from infected cells. BST2 expression is upregulated by type I interferons (IFNs) and IFN-gamma, making it a marker for interferon-stimulated genes (ISGs) and cellular activation. It is involved in cytokine trafficking within cells such as pDCs.
- Other names
- CD317HM1.24Tetherin
02
Mechanism of action
N/A
03
Biological functions
Innate immunityInterferon responseViral restrictionCytokine trafficking
04
Disease associations
HIV infectionViral infectionsAutoimmune disordersCancer (some roles in immune evasion)
05
Safety considerations
Promiscuous activation marker under inflammatory conditions reduces specificity
06
Biomarkers
Upregulation in response to Type I interferonsMarker for plasmacytoid dendritic cells (pDCs) under steady-state conditions in mice
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