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Target intelligence / Profile preview
Bone Marrow Tyrosine Kinase Gene on Chromosome X (BMX)
- Target
- BMX
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Non-receptor Tyrosine Kinase, Tec Family Kinase
01
Overview
BMX encodes a non-receptor tyrosine kinase that is part of the Tec family of kinases. It plays diverse roles in cellular signaling, including signal transduction, angiogenesis, cytokine signaling, and cell growth. Dysregulation of BMX is implicated in inflammatory diseases and cancer.
02
Mechanism of action
Selective inhibitors targeting BMX are being explored preclinically.
03
Biological functions
Signal transductionCell proliferationCell migrationCell survivalCell adhesionActin reorganizationAngiogenesisImmune responseCytokine signalingInflammationApoptosis
04
Disease associations
CancerInflammationProstatic Intraepithelial Neoplasia
05
Safety considerations
Dysregulation contributes to inflammatory diseasesOverexpression/activity may contribute to oncologic disorders
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