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Target intelligence / Profile preview
Bone Morphogenetic Protein 4
- Molecular classification
- Growth Factor, Cytokine, Signaling Molecule, TGF-beta superfamily
01
Overview
Bone morphogenetic protein 4 (BMP4) is a secreted signaling molecule belonging to the bone morphogenetic protein family and TGF-β superfamily. It plays essential roles in embryonic development and adult tissue homeostasis, including bone and cartilage formation, adipose regulation, and glucose/lipid metabolism. Aberrant BMP4 signaling is implicated in cancer and metabolic disorders. BMP4 signals through serine/threonine kinase receptors, activating SMAD-dependent transcriptional programs.
- Other names
- BMP-4BMP4BMP IVBMP-IVBMP-ABMP-BBMP-CBMP-D
02
Mechanism of action
Activation of serine/threonine kinase receptors (type I/II TGF-beta receptors) leading to SMAD-dependent transcriptional programs
03
Biological functions
Embryonic developmentBone formationCartilage formationAdipose regulationDorsal-ventral axis formationMesoderm inductionNeural tube patterningGlucose metabolism regulationLipid metabolism regulationOsteoblastic differentiation
04
Disease associations
CancerMetabolic disordersObesityInsulin resistanceMetabolic syndromeCardiovascular disease
05
Safety considerations
Potential pro-metastatic effects in certain cancer contextsModulation of inflammation/fibrosis in cardiac disease
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