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Target intelligence / Profile preview
Bone morphogenetic protein 6 (BMP6)
- Target
- BMP6
- Molecular classification
- Growth factor, TGF-beta superfamily member, Signaling molecule
01
Overview
Bone morphogenetic protein 6 (BMP6) is a secreted signaling molecule belonging to the TGF-β superfamily. It plays a critical role in various biological processes, including bone and cartilage formation, iron homeostasis, and embryonic development. BMP6 functions primarily through the activation of Smad-dependent and MAPK signaling pathways, leading to the regulation of gene transcription. Aberrant BMP6 expression is implicated in diseases such as hereditary hemochromatosis, anemia, prostate cancer metastasis to bone, and chronic obstructive pulmonary disease (COPD).
02
Mechanism of action
Signaling via Smad-dependent and MAPK pathways, regulating gene transcription related to bone formation, iron homeostasis and development.
03
Biological functions
OsteogenesisIron metabolism regulationEmbryonic developmentCell differentiationRegulation of hepcidin expressionSignaling
04
Disease associations
Hereditary hemochromatosisAnemiaProstate cancer metastasis to boneChronic obstructive pulmonary disease (COPD)
05
Safety considerations
Potential for ectopic bone formationDysregulation of iron homeostasis
06
Biomarkers
BMP6 expression levels in prostate cancer metastasisBMP6 levels in COPD patients
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