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Target intelligence / Profile preview
Bone Morphogenetic Protein 9 (BMP9)
- Target
- BMP9
- Molecular classification
- Transforming Growth Factor Beta Superfamily, Growth factor, Cytokine
01
Overview
Bone morphogenetic protein 9 (BMP9), also known as growth differentiation factor 2 (GDF2), is a member of the transforming growth factor beta (TGF-β) superfamily. It plays critical roles in maintaining endothelial integrity, bone formation, cardiac protection, and various other physiological processes. BMP9 signals primarily through ALK1 and endoglin receptors, activating Smad1/5/8 pathways. Dysregulation of BMP9 signaling is implicated in diseases like Hereditary Hemorrhagic Telangiectasia and Pulmonary Arterial Hypertension.
- Other names
- Growth Differentiation Factor 2GDF2
02
Mechanism of action
Modulates Smad signaling pathways (Smad1/5/8 activation)
03
Biological functions
OsteogenesisEndothelial maintenanceCardiac protectionIron metabolismRegulation of hepcidin expressionSmad signaling
04
Disease associations
Hereditary Hemorrhagic Telangiectasia (HHT)Pulmonary Arterial HypertensionPortal HypertensionHeart FailureCardiac Fibrosis
05
Safety considerations
Potential for off-target effects at high concentrationsRedox-dependent proteolytic regulation requires careful consideration for therapeutic use
06
Biomarkers
Plasma BMP9 levels (for Pulmonary Arterial Hypertension subtypes)
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