Bone Morphogenetic Protein Receptor Type-1 (BMPR1)

Bone morphogenetic protein receptor type-1 (BMPR1) refers to a family of transmembrane serine/threonine kinase receptors that mediate the cellular effects of bone morphogenetic proteins (BMPs). There are four type I BMP receptors: BMPR1A, BMPR1B, ACVRL1, and ACVR1. Upon ligand binding, the type II receptor phosphorylates and activates the associated type I receptor. Activated BMPR-I then phosphorylates SMAD effectors, leading to gene expression changes. BMP/BMPRI signaling regulates diverse processes including cell fate determination, apoptosis, adipocyte development, and chondrocyte differentiation. Mutations in BMPR1 genes are linked to diseases such as juvenile polyposis syndrome and fibrodysplasia ossificans progressiva.

Other names

BMPR1ABMPR1BACVRL1ACVR1ALK-2

Kinase activation via phosphorylation by type II receptor, followed by SMAD phosphorylation and gene expression regulation (canonical pathway); activation of MAPK signaling cascades (non-canonical pathway)