Bone morphogenetic protein receptor type 1A pseudogene 2 (BMPR1AP2)

Bone morphogenetic protein receptor type 1A pseudogene 2 (BMPR1AP2) is a pseudogene located on human chromosome 11[9][11]. Pseudogenes are genomic DNA sequences similar to normal genes but are non-functional; they do not encode an active protein product and typically do not contribute to biological pathways or serve as direct therapeutic targets[5][9][11]. The functional protein bone morphogenetic protein receptor type 1A (BMPR1A) is a member of the TGF-beta receptor superfamily and participates in signal transduction related to bone morphogenetic proteins, but BMPR1AP2 is not an active receptor and has no known role in disease, therapy, or drug interaction[7][11]. BMPR1AP2 should not be confused with BMPR1A, which is a functional serine/threonine kinase and a canonical receptor for bone morphogenetic proteins[7][13][14]. Instead, BMPR1AP2 is provisionally annotated as a non-coding, inactive genomic locus. No drugs or biological functions are associated with this pseudogene, and it is not suitable as a therapeutic or diagnostic target[9][11].

Other names

BMPR1APS2