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Target intelligence / Profile preview
Bone Morphogenetic Protein Receptor Type 2
- Molecular classification
- Receptor, Serine/Threonine Kinase Receptor, TGF-beta Superfamily
01
Overview
Bone morphogenetic protein receptor type 2 (BMPR2) is a transmembrane serine/threonine kinase receptor that belongs to the transforming growth factor-beta (TGF-β) superfamily. It plays a critical role in cellular signaling, development, and disease by binding bone morphogenetic proteins (BMPs) and activating SMAD transcription factors. Mutations in BMPR2 are associated with pulmonary arterial hypertension and other diseases.
02
Mechanism of action
Small molecule inhibitors targeting overactive BMPR kinases are under investigation
03
Biological functions
Signal transductionCell growthCell differentiationApoptosisOsteogenesisVasculogenesisEmbryonic developmentOrganogenesis
04
Disease associations
Pulmonary arterial hypertensionHereditary hemorrhagic telangiectasiaFibrodysplasia ossificans progressivaCancer
05
Safety considerations
Dysregulated BMP signaling
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