Bone Morphogenetic Protein Receptor Type I (BMPR-I)

Bone morphogenetic protein receptor type I (BMPR-I) refers to a family of transmembrane serine/threonine kinase receptors that mediate the cellular effects of bone morphogenetic proteins (BMPs), which are members of the transforming growth factor-beta (TGF-β) superfamily. There are two main type I BMP receptors: BMPR1A (also known as CD292) and BMPR1B. These receptors work in concert with type II BMP receptors to transduce extracellular signals into intracellular responses. Upon BMP ligand binding, a heteromeric complex forms between type II and type I receptors. The constitutively active type II receptor phosphorylates the GS domain of the associated type I receptor upon ligand engagement, activating downstream signaling pathways (Smad and MAPK). BMPR-I plays crucial roles not only in skeletal tissue induction but also broadly across embryogenesis. Mutations or dysregulation can result in developmental disorders or diseases.

Other names

BMPRIABMPR1ACD292BMPRIBBMPR1B

Serine/threonine kinase activation, Smad-dependent and MAPK signaling pathways