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Target intelligence / Profile preview
Bone morphogenetic protein receptor type IA (BMPR1A)
- Target
- BMPR1A
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase receptor, Type I BMP receptor
01
Overview
BMPR1A is a transmembrane serine/threonine kinase receptor and a member of the TGF-beta superfamily receptors. It is a type I BMP receptor that binds BMP2, BMP4, GDF5, and GDF6. It plays critical roles in embryonic development, osteogenesis, and cell differentiation. Mutations in BMPR1A are linked with juvenile polyposis syndrome.
- Other names
- CD292
02
Mechanism of action
Ligand binding to the type II receptor, recruitment of a type I receptor, phosphorylation of the type I receptor by the type II kinase, activated type I receptor phosphorylates SMAD effectors, which then mediate downstream transcriptional responses
03
Biological functions
Signal transductionEmbryonic developmentOsteogenesisExtracellular matrix depositionCell differentiationApoptosisAdipogenesisRegulation of WNT signalingTumor suppression
04
Disease associations
Juvenile polyposis syndrome
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