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Target intelligence / Profile preview
Bone morphogenetic protein receptor type IB (BMPR1B)
- Target
- BMPR1B
- Molecular classification
- Receptor, Transmembrane protein, Serine/threonine kinase, Type I receptor, TGF-beta receptor family
01
Overview
Bone morphogenetic protein receptor type IB (BMPR1B), also known as ALK6, is a transmembrane serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs), which are part of the TGF-beta superfamily. BMPR1B plays critical roles in embryogenesis, endochondral bone formation, and cellular differentiation. Upon BMP ligand binding, BMPR1B forms a heteromeric complex with type II BMP receptors, initiating intracellular signaling primarily via SMAD proteins. Mutations or dysregulation of BMPR1B have been associated with pulmonary hypertension and skeletal malformations.
- Other names
- ALK6Activin receptor-like kinase 6BMP receptor IBSerine/threonine-protein kinase receptor R6SKR6CDw293
02
Mechanism of action
Kinase activation and SMAD phosphorylation
03
Biological functions
Signal transductionEndochondral ossificationSkeletal developmentChondrogenesisOsteoblast differentiationCell survivalCell fate determination
04
Disease associations
Primary pulmonary hypertensionSkeletal malformationsBone growth disorders
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