Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Bone morphogenetic protein receptor type II
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase, TGF-beta superfamily
01
Overview
Bone morphogenetic protein receptor type II is an essential component of TGF-beta family signaling pathways regulating diverse developmental processes across tissues. Mutations disrupting its function are causally linked to heritable forms of pulmonary arterial hypertension due to abnormal vascular remodeling driven by imbalanced cellular proliferation/apoptosis dynamics.
02
Mechanism of action
Selective inhibitors targeting overactive BMPR kinases
03
Biological functions
OsteogenesisRegulation of growthRegulation of differentiationRegulation of apoptosisSignal transductionCell proliferationCell death
04
Disease associations
Pulmonary arterial hypertensionHereditary hemorrhagic telangiectasiaJuvenile hemochromatosisFibrodysplasia ossificans progressivaCardiovascular disease
Beyond the preview
Go deeper on Bone morphogenetic protein receptor type II.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Bone morphogenetic protein receptor type II.