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Bone morphogenetic protein receptor type II (None)
- Target
- None
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase, TGF-beta superfamily
01
Overview
Bone morphogenetic protein receptor type II is an essential component of TGF-beta family signaling pathways regulating diverse developmental processes across tissues. Mutations disrupting its function are causally linked to heritable forms of pulmonary arterial hypertension due to abnormal vascular remodeling driven by imbalanced cellular proliferation/apoptosis dynamics.
02
Mechanism of action
Selective inhibitors targeting overactive BMPR kinases
03
Biological functions
OsteogenesisRegulation of growthRegulation of differentiationRegulation of apoptosisSignal transductionCell proliferationCell death
04
Disease associations
Pulmonary arterial hypertensionHereditary hemorrhagic telangiectasiaJuvenile hemochromatosisFibrodysplasia ossificans progressivaCardiovascular disease
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