Bone regeneration scaffold

Bone regeneration scaffolds are three-dimensional biomaterial constructs designed to guide and enhance the repair or reconstruction of bone tissue by providing a temporary structural template for cell adhesion, proliferation, migration, and differentiation. These scaffolds may be fabricated from natural polymers (e.g., collagen, chitosan), synthetic polymers (e.g., PLA, PCL), ceramics (e.g., hydroxyapatite, tricalcium phosphate), or composites thereof. Essential features include biocompatibility, biodegradability, suitable mechanical strength, porous architecture for vascularization and tissue in-growth, and the capacity to deliver bioactive molecules (e.g., growth factors, drugs) to modulate the healing environment. Bone regeneration scaffolds are not molecular or cellular therapeutic targets themselves, but engineered devices that interact with cells and biologics to achieve clinical outcomes in bone defect repair.

Other names

Bone scaffoldbone tissue engineering scaffoldbone substitute scaffoldbone graft scaffoldBTE scaffold

Provide 3D structure for cell attachment and tissue in-growth; deliver bioactive molecules; support neovascularization; guide osteogenesis via physical and chemical cues