Bone tissue remodeling pathway

The **bone tissue remodeling pathway** is a complex physiological process involving coordinated activities of various cell types—primarily osteoclasts that resorb old or damaged bone and osteoblasts that form new bone. This cycle is essential for maintaining skeletal integrity throughout life. The process is tightly regulated by multiple signaling pathways including Wnt/β-catenin, RANK-RANKL-OPG axis, TGF-beta family members, cytokines like IL‑1β, IL‑6, TNF-alpha, growth factors such as MCSF and BMPs, as well as systemic hormones like parathyroid hormone. Dysregulation can lead to diseases such as osteoporosis or contribute to joint degeneration in osteoarthritis. While many therapeutic agents target key molecular mediators within this network—such as RANKL inhibitors or cathepsin K inhibitors—the "bone tissue remodeling pathway" itself refers broadly to an interconnected set of cellular events rather than a single druggable molecule or receptor[1][2][4][5][6].

Other names

Bone remodeling pathwayBone remodelling cycleBone homeostasis signaling pathwaysSubchondral bone remodeling pathway