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Target intelligence / Profile preview
Bordetella pertussis (whole-cell) (B. pertussis)
- Target
- B. pertussis
- Molecular classification
- Bacterium, Pathogen
01
Overview
Bordetella pertussis is a Gram-negative bacterium that is the causative agent of whooping cough (pertussis). It colonizes the ciliated epithelial cells of the respiratory tract and produces various virulence factors, including pertussis toxin, adenylate cyclase toxin, filamentous hemagglutinin, pertactin, and fimbriae, which contribute to disease pathogenesis. Humans are the only known reservoir for this pathogen. Whole-cell preparations have been used in vaccines.
- Other names
- Whooping cough bacteriumPertussis bacterium
02
Mechanism of action
Antibiotics inhibit bacterial growth and survival. Vaccines stimulate an immune response to prevent infection.
03
Biological functions
InfectionColonization of respiratory tractToxin productionImmune evasion
04
Disease associations
Whooping cough (Pertussis)Respiratory infection
05
Safety considerations
Antibiotic resistanceVaccine side effects (whole-cell vaccines)Disease complications (e.g., pneumonia, seizures, encephalopathy)
06
Interacting drugs
Antibiotics (e.g., macrolides, trimethoprim-sulfamethoxazole)
1 more in the full profile.
07
Biomarkers
B. pertussis DNA (PCR)Anti-pertussis toxin antibodiesLymphocytosis
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