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Target intelligence / Profile preview
Bordetella pertussis (whole organism) (B. pertussis)
- Target
- B. pertussis
- Molecular classification
- Bacterium, Pathogen
01
Overview
Bordetella pertussis is a small, Gram-negative, encapsulated coccobacillus bacterium that is the causative agent of whooping cough (pertussis), a highly contagious respiratory disease found only in humans. The bacteria attach to the cilia lining the upper respiratory tract, releasing toxins that damage these cells and cause airway inflammation. Key virulence factors include Pertussis toxin (PT), Adenylate cyclase toxin (ACT), Filamentous hemagglutinin (FHA), Pertactin (PRN), Fimbriae/Fimbrial agglutinogens (FIM/AGG), and Tracheal cytotoxin (TCT).
- Other names
- Whooping cough bacteria
02
Mechanism of action
Antibiotic targeting bacterial growth and protein synthesis
03
Biological functions
InfectionColonizationToxin productionAdhesion
04
Disease associations
Whooping cough (Pertussis)Respiratory infection
05
Safety considerations
Antibiotic resistanceVaccine hesitancySpread via airborne droplets
06
Interacting drugs
Azithromycin
2 more in the full profile.
07
Biomarkers
B. pertussis PCRAnti-pertussis toxin antibodiesAnti-FHA antibodies
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