Target intelligence / Profile preview

Bordetella pertussis Antigen (B. pertussis Antigen)

Target: B. pertussis Antigen
Molecular classification: Antigen, Bacterial Component, Protein, Toxin, Surface Protein, Lipopolysaccharide

Overview

Bordetella pertussis antigens are the molecular targets used in vaccines to induce immunity against *B. pertussis*, the causative agent of whooping cough. These antigens can be either whole inactivated bacterial cells (wP) or purified components (aP) such as pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN), and fimbriae. They are employed in vaccines to stimulate antibody production and cellular immunity, and also used as reagents in diagnostic immunoassays.

Other names: Whooping Cough AntigenPertussis Toxin (PT)Filamentous Hemagglutinin (FHA)Pertactin (PRN)FimbriaeWhole-cell Pertussis Antigen (wP)Acellular Pertussis Antigen (aP)

Mechanism of action

Antigen presentation leading to B-cell and T-cell activation, resulting in antibody production and cellular immunity against B. pertussis.

Biological functions

Immune Response InductionAntibody ProductionT-cell ActivationB-cell ActivationPathogen RecognitionAdhesionToxin Activity

Disease associations

InfectionWhooping CoughBordetella pertussis InfectionRespiratory Disease

Safety considerations

Reactogenicity (whole-cell vaccines)Adverse reactions (fever, pain, swelling)Limited duration of protection (acellular vaccines)Potential for waning immunityRisk of pertussis infection

Interacting drugs

Vaccines (wP, aP)

1 more in the full profile.

Biomarkers

Anti-Pertussis Toxin (PT) antibodiesAnti-Filamentous Hemagglutinin (FHA) antibodiesAnti-Pertactin (PRN) antibodiesAnti-Fimbriae antibodiesIgG levels against B. pertussis antigens

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