Bordetella pertussis antigen-specific B-cell and T-cell receptors

Bordetella pertussis antigen-specific B-cell and T-cell receptors represent the diverse repertoire of adaptive immune receptors that recognize the various components of the B. pertussis bacterium, the causative agent of whooping cough (CDC, 2023). These receptors are the primary targets of pertussis vaccines, which aim to induce long-term protective immunity by stimulating the expansion of specific B and T cell clones (Wilk et al., 2019, PMID: 30718511). B-cell receptors (BCRs) recognize surface-exposed antigens such as pertussis toxin (PT) and filamentous hemagglutinin (FHA), while T-cell receptors (TCRs) recognize bacterial peptides presented on MHC molecules, driving Th1 and Th17 responses necessary for bacterial clearance (Mills et al., 2014, PMID: 24612516). The interaction between these receptors and vaccine antigens determines the quality of the immune memory, with whole-cell vaccines typically eliciting a broader and more durable response compared to acellular formulations (Edwards & Berbers, 2014, PMID: 24842553). Understanding the repertoire of these receptors is critical for monitoring vaccine efficacy and developing next-generation immunotherapies to combat waning immunity in the population.

Other names

Pertussis-specific BCRs and TCRsB. pertussis-specific immune receptorsAnti-pertussis lymphocyte receptors

Vaccine-mediated stimulation of antigen-specific B-cell and T-cell receptors to induce protective immunological memory and antibody production.