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Bordetella pertussis Bacteria (Whole Cell) (B. pertussis (whole cell))

Target: B. pertussis (whole cell)
Molecular classification: Bacteria, Gram-negative bacteria, Pathogen, Vaccine antigen

Overview

Whole-cell Bordetella pertussis refers to chemically or physically inactivated suspensions of the bacterium used in vaccines to prevent whooping cough. Inactivation, typically with formalin or beta-propiolactone, renders the bacteria non-infectious while retaining antigenic properties necessary to induce protective immunity. While effective, whole-cell vaccines are associated with higher rates of adverse reactions compared to acellular vaccines.

Other names: Whooping cough bacteria (whole cell)Pertussis bacteria (whole cell)Inactivated B. pertussisWhole-cell pertussis vaccine antigen

Mechanism of action

Inactivated bacteria stimulate antibody production and cellular immunity against B. pertussis antigens.

Biological functions

InfectionImmune response inductionAntigen presentation

Disease associations

Whooping cough (Pertussis)

Safety considerations

Adverse reactions to whole-cell vaccine (e.g., fever, seizures)Potential for incomplete inactivationRisk of infection during handling of live cultures

Interacting drugs

Antibiotics (for treatment of infection)

2 more in the full profile.

Biomarkers

Anti-B. pertussis antibody titers (vaccine efficacy)B. pertussis DNA/RNA (infection diagnosis)

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