Target intelligence / Profile preview

Bordetella pertussis fimbrial protein 2 (Fim2)

Target: Fim2
Molecular classification: Chaperone–usher family, Fimbrial protein

Overview

Bordetella pertussis fimbrial protein 2 (Fim2) is a major structural component of the fimbriae produced by B. pertussis. It mediates adhesion to host tissues, specifically ciliated epithelial cells in the human respiratory tract, facilitating colonization and infection. Expression is phase-variable and regulated by the bvgAS system. Fim2 is a target of the immune response and is included in acellular pertussis vaccines.

Other names: Serotype 2 fimbrial subunit

Mechanism of action

Antibodies against Fim2 prevent bacterial adhesion.

Biological functions

AdhesionAttachment to ciliated respiratory epithelium

Disease associations

InfectionWhooping cough

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