Bordetella pertussis proteins (null)

Bordetella pertussis proteins include a diverse array of molecules expressed by the bacterium Bordetella pertussis, a Gram-negative human pathogen responsible for whooping cough. Key proteins include Pertussis toxin (a major exotoxin and vaccine antigen, an AB5-type toxin involved in host immune modulation and cell injury), Filamentous hemagglutinin (a large surface adhesin responsible for attachment to respiratory tract epithelium), Pertactin (an outer membrane adhesin with a beta-helix structure important for host interaction), and fimbrial proteins (involved in adhesion and colonization). These proteins function collectively in immune evasion, adherence, toxin-mediated interference with host cell signaling, and have been used as vaccine antigens. However, the term "Bordetella pertussis proteins" should not be used to denote a specific molecular target; rather, individual proteins should be specified for research, therapeutic, or diagnostic purposes. "Bordetella pertussis proteins" is not a valid singular target; entries should refer to specific proteins such as "Pertussis toxin," "Filamentous hemagglutinin," "Pertactin," or "Serotype 2 fimbrial subunit". For structured data, specify the exact protein name required.

Other names

Bordetella pertussis virulence factorsB. pertussis proteinsBordetella proteins

Vaccine-induced immune responses; neutralization of toxins; blockade of adhesion to host cells