Target intelligence / Profile preview

Bordetella pertussis Serotype 3 Fimbrial Subunit (Fim3)

Target: Fim3
Molecular classification: Protein, Adhesin, Fimbrial subunit

Overview

Bordetella pertussis serotype 3 fimbrial protein (Fimbria type III) is a key adhesin required for effective colonization during infection. Its tightly regulated expression ensures adaptation during different stages or environments encountered within hosts. As an immunodominant antigen present on vaccine strains, it plays an important role both biologically—in pathogenesis—and clinically—as part of modern vaccine formulations against whooping cough.

Other names: Fimbria type III major subunitSerotype 3 fimbrial protein

Mechanism of action

Antibodies against Fim3 inhibit bacterial adhesion

Biological functions

Adhesion to ciliated respiratory epitheliumColonizationImmune response (antigen)

Disease associations

Infection (Bordetella pertussis)Whooping cough (Pertussis)

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