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Target intelligence / Profile preview
Bordetella pertussis Whole Cell Antigen
- Molecular classification
- Bacterial Antigen, Whole Cell Immunogen
01
Overview
The Bordetella pertussis whole cell antigen consists of entire killed bacteria containing all native antigens present on/in the pathogen. It elicits broad immune responses—both humoral and cellular—and has been foundational both in early vaccine development against whooping cough and current laboratory diagnostics/research applications. Its use provides comprehensive exposure to all potential protective epitopes found on Bordetella pertussis.
- Other names
- Bordetella pertussis AntigenwP AntigenWhole-cell pertussis antigenInactivated Bordetella pertussis cells
02
Mechanism of action
Induces humoral and cellular immune responses, leading to the production of antibodies and activation of T cells specific to Bordetella pertussis antigens.
03
Biological functions
Immune stimulationAntibody productionT cell activationDiagnostic reagent
04
Disease associations
Whooping coughVaccine developmentInfectious disease research
05
Safety considerations
Potential for reactogenicity (e.g., fever, local reactions) due to the presence of various bacterial components.Use in whole-cell pertussis vaccines has been associated with rare adverse events.
06
Interacting drugs
None (used as an antigen, not a drug target)
07
Biomarkers
Anti-Bordetella pertussis antibodiesT cell responses to Bordetella pertussis antigens
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