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Target intelligence / Profile preview
Boron-10 Isotope-Containing Compound (10B Compound)
- Target
- 10B Compound
- Molecular classification
- Small Molecule, Other
01
Overview
Boron-10 isotope-containing compounds are designed for selective uptake by tumor cells. Upon neutron irradiation, the 10B atoms undergo nuclear fission, releasing high-energy alpha particles and lithium ions that cause localized cytotoxicity, primarily affecting cancer cells. Examples of these compounds are Boronophenylalanine (BPA) and Sodium borocaptate (BSH). The therapeutic effectiveness relies on achieving a high tumor-to-normal tissue boron concentration ratio and optimizing neutron beam parameters.
- Other names
- Boronophenylalanine (BPA)Sodium borocaptate (BSH)Boronated drugs for BNCT
02
Mechanism of action
Selective accumulation in tumor cells followed by neutron-induced nuclear fission, resulting in localized alpha particle and lithium ion emission and subsequent cell death.
03
Biological functions
Drug DeliveryCell Death InductionRadiosensitization
04
Disease associations
Cancer
05
Safety considerations
Non-specific uptake in normal tissuesRadiation damage to healthy tissueOptimization of neutron beam parametersAchieving sufficient tumor boron concentrationDrug delivery and diffusion limitations
06
Interacting drugs
Boronophenylalanine (BPA)
1 more in the full profile.
07
Biomarkers
Tumor boron concentrationTumor-to-normal tissue boron concentration ratioCell cycle phase (for BPA uptake)
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