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Boron Neutron Capture
- Molecular classification
- Nuclear Reaction, Radiotherapy Technique
01
Overview
Boron Neutron Capture (BNCT) is a cancer therapy that exploits the nuclear reaction between non-radioactive boron-10 (^10B) and neutrons to selectively destroy tumor cells. The process involves administering a ^10B-containing compound that preferentially accumulates in the tumor, followed by irradiation with low-energy neutrons. Neutron capture by ^10B results in the emission of high-LET alpha particles and lithium nuclei with short ranges, causing localized cell death.
02
Mechanism of action
Neutron capture by ^10B followed by emission of alpha particle and lithium nucleus, resulting in localized cell destruction via high-LET radiation.
03
Biological functions
Cell deathTumor cell ablation
04
Disease associations
Cancer
05
Safety considerations
Efficient delivery of ^10B to tumor cellsMinimizing ^10B uptake in normal tissuesAvailability of suitable neutron sourcesRadiation toxicity to normal tissuesHeterogeneous boron distribution within tumors
06
Interacting drugs
Sodium borocaptate (BSH)
1 more in the full profile.
07
Biomarkers
Tumor boron concentrationNormal tissue boron concentration
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