Target intelligence / Profile preview

Borrelia burgdorferi (Bb)

Target: Bb
Molecular classification: Bacterium, Spirochete

Overview

Borrelia burgdorferi is a species of spirochete bacteria and the primary causative agent of Lyme disease in humans. It is transmitted to humans through the bite of infected blacklegged ticks (genus Ixodes). Infection leads to multi-stage illness if untreated, beginning with localized skin lesions progressing potentially toward systemic involvement affecting joints, heart, and the nervous system. The pathology results primarily from host immune responses rather than classical bacterial toxins.

Mechanism of action

Antibiotics inhibit bacterial growth by targeting essential bacterial processes such as cell wall synthesis or protein synthesis.

Biological functions

InfectionHost immune response elicitationMotility

Disease associations

Lyme diseaseArthritisCarditisNeurological symptoms/encephalopathy

Safety considerations

Antibiotic resistanceJarisch-Herxheimer reactionPost-treatment Lyme disease syndrome (PTLDS)

Interacting drugs

Doxycycline

2 more in the full profile.

Biomarkers

Erythema migransAntibody detection (ELISA, Western blot)PCR for B. burgdorferi DNA

Beyond the preview

Go deeper on Borrelia burgdorferi (Bb).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Borrelia burgdorferi (Bb).

Explore the full profile