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Borrelia burgdorferi Antigen
- Molecular classification
- Lipoprotein, Surface Protein, Adhesin, Flagellin
01
Overview
Borrelia burgdorferi antigens are molecular components (primarily proteins) of the Lyme disease-causing bacterium that are recognized by the host immune system. These antigens, including surface lipoproteins, flagellin, OspC, DbpA, VlsE, and BBF01, elicit antibody responses and are used as diagnostic markers. Antigenic variation allows B. burgdorferi to evade the immune system, complicating diagnosis and treatment.
- Other names
- B. burgdorferi antigenLyme disease antigen41-kDa Flagellin ProteinOspC (Outer Surface Protein C)DbpA (Decorin-Binding Protein A)VlsE (Variable major protein-like sequence Expressed)BBF01
02
Biological functions
Immune evasionHost cell adhesionStimulation of antibody responseModulation of host innate defenses
03
Disease associations
Lyme diseaseInfectionInflammation
04
Safety considerations
Antigenic variation leading to diagnostic challengesPotential for false negatives in early-stage Lyme diseaseDifficulty in achieving sterilizing immunity due to immune evasion mechanisms
05
Biomarkers
Antibody levels against B. burgdorferi antigens (IgM, IgG)
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