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Target intelligence / Profile preview
Borrelia Outer Surface Proteins (Osp)
- Target
- Osp
- Molecular classification
- Lipoprotein, Outer membrane protein, Adhesin, Surface protein
01
Overview
Borrelia outer surface proteins (Osps) are a diverse group of membrane-associated proteins found on the surface of Borrelia species, most notably *Borrelia burgdorferi*. These proteins play critical roles in the bacterium’s lifecycle, including dissemination, virulence, tissue tropism, immune evasion, and host-pathogen interactions. OspA and OspC are among the most studied, with OspA being predominantly expressed in ticks and OspC during mammalian infection. Many Osps are immunogenic and have been targets for vaccine development. Their expression is tightly regulated, and they mediate adhesion to host tissues and contribute to immune evasion.
- Other names
- Borrelia OspsOspAOspCOspBOspDOspEOspFDbpADbpBCspAVlsEP13P66BesCBamALmp1BB0405BBK32
02
Mechanism of action
Various, including adhesion, immune evasion, and host cell interaction
03
Biological functions
Host cell adhesionImmune evasionTick colonizationMammalian infectionExtracellular matrix bindingComplement regulation
04
Disease associations
Lyme diseaseBorrelia infection
05
Safety considerations
Antigenic variation leading to vaccine escapeStrain-specific efficacy of vaccinesPotential for immune-mediated pathology
06
Biomarkers
Antibody levels against specific Osps (e.g., OspC)
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