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Target intelligence / Profile preview
Botulinum Neurotoxin (BoNT)
- Target
- BoNT
- Molecular classification
- Enzyme, Endopeptidase, Neurotoxin
01
Overview
Botulinum neurotoxin (BoNT) is a highly potent neurotoxic protein produced by *Clostridium botulinum*. It functions as a zinc-dependent endopeptidase that cleaves SNARE proteins essential for acetylcholine vesicle fusion with the neuronal membrane, thereby blocking neurotransmission and causing flaccid paralysis. BoNTs have various serotypes (A-G) with differing substrate specificities. While highly toxic, BoNT is also used in controlled doses for therapeutic applications, such as treating muscle overactivity and cosmetic reduction of wrinkles.
- Other names
- Botulinum toxinBoNT/ABoNT/BBoNT/CBoNT/DBoNT/EBoNT/FBoNT/GBotox
02
Mechanism of action
Cleaves SNARE proteins (SNAP-25, synaptobrevin, syntaxin) at presynaptic nerve terminals, preventing acetylcholine release.
03
Biological functions
Inhibition of neurotransmitter releaseMuscle paralysisSynaptic transmission modulation
04
Disease associations
BotulismMuscle spasticityDystonia
05
Safety considerations
Respiratory paralysisMuscle weaknessDifficulty swallowingPotential for systemic spread
06
Interacting drugs
Acetylcholinesterase inhibitors (indirect)
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