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Target intelligence / Profile preview
Botulinum Neurotoxin A (BoNT/A)
- Target
- BoNT/A
- Molecular classification
- Toxin, Enzyme, Metalloprotease
01
Overview
Botulinum neurotoxin A (BoNT/A) is a highly potent neurotoxic protein produced by *Clostridium botulinum*. It acts as a zinc-dependent endopeptidase that cleaves SNAP-25, a SNARE protein essential for acetylcholine release, resulting in flaccid paralysis. BoNT/A is used therapeutically to treat dystonia, muscle spasticity, hyperhidrosis, and migraines, and cosmetically for wrinkle reduction.
- Other names
- Botulinum toxin type ABoNT AClostridium botulinum neurotoxin ABotox
02
Mechanism of action
Blocks acetylcholine release by cleaving SNAP-25, a SNARE protein, at the neuromuscular junction and other cholinergic synapses.
03
Biological functions
Neurotransmission inhibitionSNARE protein cleavageAcetylcholine release blockadeParalysis induction
04
Disease associations
BotulismDystoniaMuscle spasticityMigraineHyperhidrosis
05
Safety considerations
Systemic spread leading to botulismRespiratory paralysisAntibody formation reducing efficacyInjection site reactionsOverdose leading to excessive muscle weakness
06
Interacting drugs
Botulinum toxin A products (e.g., Botox, Dysport, Xeomin)
1 more in the full profile.
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