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Target intelligence / Profile preview
Botulinum Neurotoxin C (BoNT/C)
- Target
- BoNT/C
- Molecular classification
- Enzyme, Neurotoxin, Metalloprotease
01
Overview
Botulinum neurotoxin C (BoNT/C) is a highly potent neuroparalytic toxin produced by Clostridium botulinum. It functions as a zinc-dependent endopeptidase that cleaves SNARE proteins (SNAP-25 and syntaxin-1) at presynaptic nerve terminals, blocking acetylcholine release and causing flaccid paralysis. BoNT/C is associated with animal botulism and is a potential bioterrorism agent, but is also used therapeutically for conditions involving excessive nerve activity.
02
Mechanism of action
Cleaves SNAP-25 and syntaxin-1, preventing acetylcholine release.
03
Biological functions
Neurotransmitter release inhibitionMuscle paralysisSynaptic vesicle fusion disruption
04
Disease associations
BotulismMuscle spasticity (therapeutic target)
05
Safety considerations
High toxicityRisk of paralysisPotential for bioterrorism
06
Interacting drugs
Botulinum toxin type C
1 more in the full profile.
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