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Target intelligence / Profile preview
Botulinum Neurotoxin D (BoNT/D)
- Target
- BoNT/D
- Molecular classification
- Enzyme, Metalloprotease, Toxin
01
Overview
Botulinum neurotoxin D (BoNT/D) is one of the seven major serotypes (A–G) of botulinum neurotoxins produced by the bacterium *Clostridium botulinum* and related species. These toxins are among the most potent biological substances known, causing flaccid paralysis by blocking neurotransmitter release at neuromuscular junctions. It binds specifically to presynaptic membranes at cholinergic nerve terminals and cleaves SNARE proteins—specifically VAMP/synaptobrevin—disrupting synaptic vesicle fusion with the plasma membrane.
02
Mechanism of action
The light chain cleaves SNARE proteins—specifically VAMP/synaptobrevin—disrupting synaptic vesicle fusion with the plasma membrane. This prevents acetylcholine release, resulting in flaccid paralysis
03
Biological functions
Neurotransmitter release inhibitionSynaptic vesicle fusion disruptionSNARE protein cleavage
04
Disease associations
BotulismFlaccid paralysis
05
Safety considerations
Extreme potencyRisk of botulism
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