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Target intelligence / Profile preview
Botulinum Neurotoxin Serotype B (BoNT/B)
- Target
- BoNT/B
- Molecular classification
- Metalloprotease, Neurotoxin, Enzyme
01
Overview
Botulinum neurotoxin serotype B (BoNT/B) is a highly potent neurotoxic protein produced by Clostridium botulinum. It functions as a zinc-dependent metalloprotease, cleaving synaptobrevin (VAMP), a SNARE protein essential for neurotransmitter release, thus inhibiting acetylcholine exocytosis and causing flaccid paralysis. Controlled doses are used therapeutically for various neuromuscular disorders.
- Other names
- Botulinum toxin BClostridium botulinum neurotoxin serotype B
02
Mechanism of action
Metalloprotease that cleaves synaptobrevin (VAMP), a SNARE protein, preventing acetylcholine exocytosis at neuromuscular junctions, leading to flaccid paralysis.
03
Biological functions
Neurotransmission inhibitionAcetylcholine release inhibitionSNARE protein cleavageMetalloprotease activity
04
Disease associations
BotulismNeuromuscular disorders
05
Safety considerations
High toxicityPotential for paralysisRisk of respiratory failure
06
Interacting drugs
Botulinum toxin type B (therapeutic)
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