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Target intelligence / Profile preview
Botulinum neurotoxin serotype C (None)
- Target
- None
- Molecular classification
- Enzyme, Toxin, Endopeptidase
01
Overview
Botulinum neurotoxin serotype C (BoNT/C) is a highly potent neurotoxic protein produced by *Clostridium botulinum*. It is a zinc-dependent endopeptidase that cleaves SNARE proteins, specifically syntaxin-1A/1B and SNAP-25, inhibiting acetylcholine release at neuromuscular junctions. This results in flaccid paralysis. While primarily associated with animal botulism, it has potential therapeutic applications but is classified as a category A select agent due to its toxicity.
02
Mechanism of action
Zinc-dependent endopeptidase; cleaves SNARE proteins (syntaxin-1A/1B and SNAP-25), inhibiting acetylcholine release at neuromuscular junctions, leading to flaccid paralysis.
03
Biological functions
Neurotransmitter release inhibitionSynaptic vesicle fusion disruptionSNARE protein cleavageNeurotransmission blockade
04
Disease associations
BotulismFlaccid paralysis
05
Safety considerations
High toxicityPotential use as a biological weaponRisk of flaccid paralysisLimited therapeutic window
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