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Target intelligence / Profile preview
Botulinum Neurotoxin Serotype E (BoNT/E)
- Target
- BoNT/E
- Molecular classification
- Enzyme, Metalloprotease, Toxin
01
Overview
Botulinum neurotoxin serotype E (BoNT/E) is one of the seven major serotypes of botulinum neurotoxins produced by Clostridium species. BoNT/E is a primary cause of human botulism, a potentially lethal paralytic disease that targets cholinergic nerve terminals. It is synthesized as an inactive single-chain polypeptide, which becomes active after proteolytic cleavage into a heavy and light chain. The light chain is a zinc-dependent metalloprotease that cleaves SNAP-25, a SNARE protein essential for acetylcholine release, leading to flaccid paralysis. While highly toxic, controlled doses are used therapeutically to treat certain neuromuscular disorders due to its ability to induce temporary muscle relaxation.
- Other names
- Botulinum toxin EBoNT EClostridium botulinum neurotoxin serotype E
02
Mechanism of action
Cleaves SNAP-25, a SNARE protein essential for acetylcholine release, thereby blocking neurotransmitter exocytosis and causing flaccid paralysis.
03
Biological functions
Neurotransmitter release inhibitionSNAP-25 cleavageNeuromuscular blockadeSynaptic transmission inhibition
04
Disease associations
BotulismNeuromuscular disorders
05
Safety considerations
High toxicityPotential for systemic paralysisRisk of botulismAntibody development (therapeutic use)Spread of toxin within neural tissue
06
Interacting drugs
Antitoxins (BoNT/E specific)
2 more in the full profile.
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