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Botulinum Neurotoxin Serotype G (BoNT/G)

Target: BoNT/G
Molecular classification: Enzyme, Metalloprotease, Neurotoxin

Overview

Botulinum neurotoxin serotype G (BoNT/G) is one of the seven antigenically distinct serotypes of botulinum neurotoxins. It blocks neurotransmitter release at neuromuscular junctions by cleaving VAMP/synaptobrevin within the SNARE complex, leading to flaccid paralysis. BoNT/G binds neurons via Synaptotagmin I and gangliosides. It exists as part of a toxin complex with NTNH, HA70, and HA17 proteins.

Mechanism of action

Cleaves VAMP/synaptobrevin SNARE protein; inhibits acetylcholine release

Biological functions

Neurotransmitter release inhibitionSNARE protein cleavageSynaptic vesicle fusion disruption

Disease associations

BotulismParalysis

Safety considerations

Potentially lethal paralytic illnessRespiratory failure

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