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Target intelligence / Profile preview
Botulinum Neurotoxin Type B (BoNT/B)
- Target
- BoNT/B
- Molecular classification
- Toxin, Enzyme, Protease
01
Overview
Botulinum neurotoxin type B (BoNT/B) is a protein neurotoxin produced by the bacterium *Clostridium botulinum* type B. It is synthesized as an inactive single-chain polypeptide (~150 kDa), which becomes active after proteolytic cleavage into heavy and light chains. The light chain cleaves vesicle-associated membrane protein 2 (VAMP2/synaptobrevin II), a key component of the SNARE complex required for acetylcholine vesicle fusion, blocking acetylcholine release and causing flaccid paralysis.
02
Mechanism of action
Cleaves VAMP2/synaptobrevin II, blocking acetylcholine release at neuromuscular junctions and autonomic nerve endings, resulting in flaccid paralysis or inhibition of glandular secretion.
03
Biological functions
Neurotransmission InhibitionProteolysisNeuromuscular blockade
04
Disease associations
BotulismMuscle SpasticityDystonia
05
Safety considerations
Potential for unintended paralysisRisk of botulism if improperly handledAntibody development leading to reduced efficacy
06
Interacting drugs
Myobloc
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