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Target intelligence / Profile preview
Botulinum Neurotoxin Type C (BoNT/C)
- Target
- BoNT/C
- Molecular classification
- Toxin, Metalloprotease
01
Overview
Botulinum neurotoxin type C (BoNT/C) is a highly potent neurotoxic protein produced by *Clostridium botulinum*. It cleaves SNAP-25 and syntaxin, SNARE proteins essential for acetylcholine release, leading to flaccid paralysis. BoNT/C is associated with botulism outbreaks, especially in animals, and uniquely induces motoneuron degeneration.
02
Mechanism of action
The light chain of BoNT/C functions as a zinc-dependent metalloprotease that cleaves SNAP-25 and syntaxin, SNARE proteins essential for acetylcholine release at neuromuscular junctions, leading to flaccid paralysis.
03
Biological functions
Neurotransmission InhibitionSNARE Protein CleavageMotoneuron DegenerationParalysis Induction
04
Disease associations
BotulismNeuromuscular Paralysis
05
Safety considerations
High potency and lethalityRisk of respiratory failurePotential for long-term neurological effectsDifficult to treat due to rapid onset of action
06
Interacting drugs
Botulinum antitoxin
2 more in the full profile.
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