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Target intelligence / Profile preview
Botulinum Neurotoxin Type D (BoNT/D)
- Target
- BoNT/D
- Molecular classification
- Enzyme, Metalloprotease, Toxin
01
Overview
Botulinum neurotoxin type D (BoNT/D) is a potent neurotoxic protein produced by *Clostridium botulinum*. It causes flaccid paralysis by inhibiting acetylcholine release at neuromuscular junctions through cleavage of the SNARE protein VAMP2. While highly toxic to certain animals, it exhibits lower toxicity in humans due to inefficient cleavage of the human VAMP1 isoform. Crystal structure data are available under PDB ID: 2FPQ.
- Other names
- Botulinum toxin DClostridium botulinum type D
02
Mechanism of action
Cleaves VAMP2, inhibiting acetylcholine release at neuromuscular junctions, resulting in flaccid paralysis.
03
Biological functions
Inhibits acetylcholine releaseNeurotransmission inhibitionSNARE complex disruption
04
Disease associations
Animal botulismFlaccid paralysis
05
Safety considerations
High toxicity in animals (mice, cattle, horses)Potential for outbreaks in livestock
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