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Target intelligence / Profile preview
Botulinum Neurotoxin Type G (BoNT/G)
- Target
- BoNT/G
- Molecular classification
- Enzyme, Metalloprotease, Neurotoxin
01
Overview
Botulinum neurotoxin type G (BoNT/G) is a potent neurotoxin produced by *Clostridium botulinum*. It functions as a zinc-dependent metalloprotease that cleaves VAMP/synaptobrevin, a SNARE protein essential for acetylcholine release at neuromuscular junctions. This cleavage disrupts vesicle fusion, leading to flaccid paralysis. BoNT/G binds to neurons via Synaptotagmin I and gangliosides. While less frequently implicated in human botulism compared to other serotypes, its extreme toxicity makes it a significant potential biothreat.
02
Mechanism of action
Blocks acetylcholine release via cleavage of VAMP/synaptobrevin after specific binding/entry into motor neurons.
03
Biological functions
Neurotransmitter release inhibitionSynaptic transmission disruptionVAMP/synaptobrevin cleavageParalysis induction
04
Disease associations
BotulismNeuroparalytic diseasePotential bioterrorism agent
05
Safety considerations
Extreme toxicityPotential for misuse as a bioweaponRisk of flaccid paralysisLimited clinical data compared to other BoNT serotypes
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